nicotine risk factors
Scientists are reporting the first successful strategy to reduce dependence on nicotine smokers while so that they continue to smoke. The Study provides strong support for proposals now in Congress as FDA regulation of cigarette smoking to approve, according to the research team.
The Key to the success of the clinical study was to provide smokers with cigarettes gradually decreasing nicotine content over several weeks. If such cigarettes were federal funds forward would help smokers find it easier to quit, and more young smokers could avoid addiction, according to scientists. Tobacco company products as low marketed nicotine alternatives, in fact, do not change the level of nicotine in smokers, they added.
The research by scientists at UCSF and San Francisco General Hospital Medical Center and will be carried out in the 14th November issue of the journal "Cancer Epidemiology, Biomarkers & Prevention reported."
Legislation specifying the FDA authority to regulate tobacco products which is currently under consideration in Congress. Such regulatory authority would be the agency to develop and enforce authorize the standards for cigarettes less, harmful – including the reduction of nicotine yields so that cigarettes would be less addictive, said, Neal Benowitz, MD, director of the study team and an expert on the pharmacology and health effects of nicotine and other tobacco products.
Smoking and health experts worried that smoking would reduce the nicotine content of cigarettes to a greater number of cigarettes and therefore increased exposure to tobacco smoke of others Toxins, as in the smokers you see the currently marketed low-nicotine yield cigarettes, Benowitz said. The new study on reduced nicotine content cigarettes strongly Counters that prediction.
In the study, 20 healthy adult smokers smoked their usual brand for a week and then a six-week fast of cigarettes was followed with more decreased nicotine content.
At the end of this time they were released back to their usual commercial cigarette brand, and most of them did. In examining one months Later, they were smoking about 40 percent fewer cigarettes per day, with a comparable reduction in nicotine intake, compared to when the study started. Still promising to smoke, stop one quarter of smokers, while was ongoing throughout the study, the researchers found.
"This Study supports the idea that if tobacco companies were required to the amounts of nicotine collapse, could begin cigarettes "> cigarettes, tobacco, young people taking up smoking to avoid becoming addicted to drugs and could reduce long-term smokers or at the end of smoking, Benowitz said.
"This could spare millions of people from the serious health consequences of years of smoking," added he added.
Benowitz is a UCSF professor of medicine, psychiatry and biopharmaceutical sciences, and Chief, Division of Clinical Pharmacology and Experimental Therapeutics at SFGH. In 1994, Benowitz and colleague Jack Henningfield proposed in the New England Journal of Medicine "federal regulations should require cigarette manufacturers to gradually nicotine of all cigarettes sold in the United States to reduce
Scientists have conducted studies to test nicotine-reduction strategies, using commercial low-yield cigarettes. Such cigarettes, to reduce nicotine levels, when tested by smoking machines because manufacturers have designed cigarettes to burn faster, and they have highly porous Paper and ventilation holes above the filter is used. These cigarettes contain significant levels of nicotine and such "cigarette engineering" does not to decreased nicotine intake, because smokers are easily able to nicotine, by more frequent and larger trains, Benowitz and his co-authors will be noted for.
In contrast, in the new study, the absolute content of nicotine in tobacco was reduced so that it can compensate for very difficult or even impossible by smoking more. In addition to the reduced smoking and nicotine levels, the UCSF scientists looked for changes in exposure to carbon monoxide, tobacco smoke carcinogens and cardiovascular disease Risk factors. All these remained stable or declined, showing that smokers not exposed to higher tobacco smoke toxins when they switched, and therefore not in danger be brought by a nicotine reduction intervention.
Benowitz and his colleagues now carry a much larger and longer clinical study on the efficacy and Security of reducing the nicotine content of cigarettes. They plan to examine whether reduced nicotine cigarettes as a lower dependence potential of the young experimental Smokers.
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Article Source: ArticlesBase.com – Nicotine Addiction Slashed in Test of New Cigarette Smoking Strategy
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